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KMID : 0359319910310010041
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Korean Journal of Veterinary Research
1991 Volume.31 No. 1 p.41 ~ p.47
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Protective influence of selenium on nitrite - induced methemoglobinemia in rabbits
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Abstract
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The protective of influences of sodium selenite (Na₂SeO₃) against the methemoglobinemia with sodium nitrite were investigated on hemoglobin, methemoglobin, glutathione peroxidase and NADH-methemoglobin reductase activity in rabbits which were given 0, 1, 3 and 9ppm sodium selenite of drinking water for a week. Dietary selenium did not alter total hemoglobin in the blood of rabbits. Selenium was found to decrease nitrite-induced methemoglobin in a close-dependent manner. The glutathione peroxidase activity was also increased by selenium in all the experimental groups. However, the NADH-methemoglobin reductase activity by selenite did not show significant differences as concerns the methemoglobinemia. These results showed that selenium could inhibit nitrite-induced methemoglobinemia. Its influence of inhibition is suggested thst the effect of the reduction of methemoglobin was greatly stimulated by glutathione peroxidase activity.
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